We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

A theory of the first-person plural occupies a unique place in philosophical investigations into intersubjectivity and social cognition. In order for the referent of the first-person plural—“the We”—to come into existence, it seems there must be a shared ground of communicative possibility, but this requires a non-circular explanation of how this ground could be shared in the absence of a pre-existing context of communicative conventions. Margaret Gilbert’s and John Searle’s theories of collective intentionality capture important aspects of the We, (...) but fail to fully account for this shared ground of communicative possibility. This paper argues that Merleau-Ponty’s concept of intercorporeity helps reconcile the positive aspects of these accounts while also explaining how the genesis of the social world is continuous with perceptual life in general. This enables an account of the first-person plural as dependent on reciprocal communicative interaction without the need to posit a primitive or primordial “we-mode” of consciousness. “Intercorporeity” designates a bodily openness to others that is not fundamentally different in kind from the general style of bodily comportment found in Merleau-Ponty’s rich analyses of perceptual life. (shrink)

Book Information A Theory of Justice: Revised Edition. By John Rawls. Oxford University Press. Oxford. 1999. Pp. xxii + 538. Hardback, £25.00. Paperback, £12.99.

Since the publication of Jonathan Dancy's 'Moral Reasons' in 1991, many English speaking ethicists have been especially interested in the role of abstract theory in moral life and the extent to which principles analogous to those employed in the hard sciences like physics are central to the development of ethical knowledge. Unlike earlier generations of philosophers who had, on the whole, accepted that principles had an integral role in the life of a morally serious person, contemporary ethicists are largely divided (...) about the merits of such principles and whether ethical knowledge is gained through principles. This debate about the form of ethical knowledge raises questions about the epistemic status of intuitions. Can intuitions about right and wrong provide an alternative source of genuine ethical knowledge? Is reflection upon a belief enough to show that it is true? This edited collection, consisting of 11 essays by distinguished philosophers, pursues and advances that debate. The early chapters of the book are concerned primarily with intuitions and intuitionism. John Cottingham, in an essay that casts doubt on the possibility of secular intuitions, argues that if intuitions are uprooted from their traditional theological foundations then they lose their plausibility. The claim is that theism and moral intuitionism are natural partners and morality is doomed if we reject theistic picture that 'provides a home for these intuitions'. James Lenman provides an indirect response to Cottingham, questioning whether evolutionary explanations of intuitions genuinely debunk them. Explaining the causal origins of intuitions within a naturalistic framework is not damning of them or of morality itself. (shrink)

In a previous article in this journal, we examined John Dupré's claim that ‘scientific imperialism’ can lead to ‘misguided’ science being considered acceptable. Here, we address criticisms raised by Ian J. Kidd and Uskali Mäki against that article. While both commentators take us to be offering our own account of scientific imperialism that goes beyond that developed by Dupré, and go on to criticise what they take to be our account, our actual ambitions were modest. We intended to ‘explicate (...) the sense in which the term is used by Dupré’ and to ‘identify the normative content of his critique of scientific imperialism’. We made no claim to have developed our own account of scientific imperialism that went further than what was implicit in Dupré's work already. However, that said, the discussions presented by both Kidd and Mäki raise important general issues about how the idea of scientific imperialism should be understood and framed. Here, we offer our considered responses to Kidd's and Maki's discussions of scientific imperialism. (shrink)

It took nearly two thousand years for society to recognize the Hippocratic insistence that “the doctor knows best”1 was an inadequate approach to medical decisionmaking. Today, patient-centered medicine has come to understand that the individual patient has a significant role in the decisionmaking process.2.

Reporting peers’ counterproductive work behaviors (CWBs) is important for maintaining an ethical organization, but is a significant and potentially risky action. In Bandura’s Theory of Moral Thought and Action (Bandura, 1991) he states that such acts require significant moral agency, which is generated when an individual possesses adequate moral self-regulatory capacities to address the issue and is in a context that activates and reinforces those capacities. Guided by this theory, we assess moral potency (i.e., moral courage, moral efficacy, and moral (...) ownership) as key capacities predicting peer reporting intentions and assess three contextual factors influencing the generation and effects of moral potency: whether a potential informant (1) works for an ethical leader, (2) is embedded in a psychologically safe climate promoting interpersonal risk-taking, and (3) operates in a more normal or extreme context. We assess the proposed model across three field studies entailing both normal and extreme (i.e., firefighting units) contexts. Results show that ethical leaders raise employees’ moral potency, promoting greater willingness to report their peers’ CWBs. In normal work contexts, psychological safety positively moderated both the relationship between ethical leadership and moral potency and between moral potency and peer reporting intentions. However, psychological safety had the opposite effects in more extreme work contexts. Whereas psychological safety strengthens the positive association between moral potency and peer reporting intentions in normal work contexts, in contexts where individuals are more frequently exposed to extreme events, psychological safety weakens this relationship, thus highlighting the unforeseen downsides of psychological safety in extreme contexts. (shrink)

Here, in a single volume, is a comprehensive and definitive account of pragmatism and classical American philosophy. Pragmatism and Classical American Philosophy, now revised and expanded in this second edition, presents the essential writings of the major philosophers of this tradition: Charles S. Peirce, William James, Josiah Royce, George Santayana, John Dewey, and George Herbert Mead. Illuminating introductory essays, written especially for this volume by distinguished scholars of American philosophy, provide biographical and cultural context as well as original critical (...) and interpretive perspectives. This edition also includes all new selections and interpretive essays that situate pragmatism and classical American philosophy in a wider American philosphical context, including: Ralph Waldo Emerson and transcendentalism; Jane Addams, feminism, and writings of American women; Borden Parker Bowne, personalism, and idealism; Alain Locke and Afro-American thought; and John Herman Randall, Jr., nationalism and realism. Up-to-date suggestions for further reading will benefit both introductory and advanced readers. This American intellectual tradition speaks insightfully, creatively, and critically to our contemporary global society and its pressing problems. In unmatched quality and quantity, Pragmatism and Classical American Philosophy provides the resources necessary to understand and act on these insights. (shrink)

Pragmatism, Postmodernism and the Future of Philosophy is a vigorous and dynamic confrontation with the task and temperament of philosophy today. In this energetic and far-reaching new book, Stuhr draws persuasively on the resources of the pragmatist tradition of James and Dewey, and critically engages the work of Continental philosophers like Adorno, Foucault, and Deleuze, to explore fundamental questions of how we might think and live differently in the future. Along the way, the book addresses important issues in public policy, (...) university administration, spirituality, and the notion of community and its meaning in a global world of difference. This book is essential reading for anyone concerned with the future of philosophy, and the ways in which philosophical thinking can help us live better, more fulfilling lives. (shrink)

The adolescing self -- Imaging and fettered imaging -- Characteristics of the superego God -- Adolescing religion and formal religion -- Images of the superego God -- The adult self -- Unfettered imaging and religious experiencing -- Characteristics of the living God -- Adult religion and integral spirituality -- Images of the living God -- Transformation and why it gets so little attention -- What hinders transformation -- What facilitates transformation -- Images of transformation.

[If you find this article interesting, let me mention another of my articles, “On Deducing Ethical Egoism from Psychological Egoism” (Theoria, 2023), which in many ways is a more thorough treatment of the topic. But it’s not an expanded version of this one. For instance, each article addresses arguments not addressed in the other.] Philosophers generally reject the view that psychological egoism (suitably supplemented with further premises) entails ethical egoism. Their rejections are generally unsatisfying. Some are too brief to win (...) confidence; others employ an uncharitable statement of psychological egoism. This is unfortunate, for the view that psychological egoism entails ethical egoism is philosophically significant (and not without proponents). Although it ultimately deserves rejection, it warrants better treatment than it typically receives. I thus examine it in some detail. Among other things, I carefully consider some original, sophisticated attempts to establish it, having first taken care to produce proper formulations of ethical and psychological egoism. (shrink)

Long recognized as one of the main branches of political science, political theory has in recent years burgeoned in many different directions. Close textual analysis of historical texts sits alongside more analytical work on the nature and normative grounds of political values. Continental and post-modern influences jostle with ones from economics, history, sociology, and the law. Feminist concerns with embodiment make us look at old problems in new ways, and challenges of new technologies open whole new vistas for political theory. (...) This Handbook provides comprehensive and critical coverage of the lively and contested field of political theory, and will help set the agenda for the field for years to come. Forty-five chapters by distinguished political theorists look at the state of the field, where it has been in the recent past, and where it is likely to go in future. They examine political theory's edges as well as its core, the globalizing context of the field, and the challenges presented by social, economic, and technological changes."This is a unique and impressive set of analyses about scholarship in political theory. It is comprehensive, as we would expect. Beyond that, it is remarkably creative in the way that Dryzek, Honig and Phillips have organized categories, and it includes much overdue reference to scholarship on non-Western and postcolonial thought."-Iris Marion Young, Late Professor of Political Science at the University of Chicago"This extraordinary series offers 'state of the art' assessments that instruct, engage, and provoke. Both synoptic and directive, the fine essays across these superbly edited volumes reflect the ambitions and diversity of political science. No one who is immersed in the discipline's controversies and possibilities should miss the intellectual stimulation and critical appraisal these works so powerfully provide."-Ira Katznelson, Ruggles Professor of Political Science and History, Columbia UniversityJohn S. Dryzek is Professor of Social and Political Theory at Australian National University.Bonnie Honig is Professor of Political Science at Northwestern University.Anne Phillips is Professor of Gender Theory at the London School of Economics.Introduction, John S Dryzek, Bonnie Honig, and Anne PhilipsI. CONTEMPORARY CURRENTS1. Justice After Rawls, Richard Arneson2. Power After Foucault, Wendy Brown3. Critical Theory Beyond Habermas, William E Scheuerman4. Feminist Theory and the Canon of Political Thought, Linda Zerilli5. After the Linguistic Turn: Poststructuralist and Liberal Pragmatist Political Theory, Paul Patton6. The Pluralist Imagination, David SchlosbergII. THE LEGACY OF THE PAST7. Theory in History: Problems of Context and Narrative, J G A Pocock8. The Political Theory of Classical Greece, Jill Frank9. Republican Visions, Eric Nelson10. Modernity and its Critics, Jane Bennett11. The History of Political Thought, as Disciplinary Genre, James FarrIII. POLITICAL THEORY IN THE WORLD12. The Challenge of European Union, Richarad Bellamy13. East Asia and the West: The Impact of Confucianism on Anglo-American Political Thought, Daniel A Bell14. In the Beginning all the World was America: American Exceptionalism in New Contexts, Ronald J Schmidt Jr15. Changing Interpretations of Modern and Contemporary Islamic Political Theory, Roxanne L EubenIV. STATE AND PEOPLE16. Constitutionalism and the Rule of Law, Shannon Stimson17. Emergency Powers, John Ferejohn and Pasquale Pasquino18. The People, Margaret Canovan19. Civil Society and State, Simone Chambers and Jeffrey Kopstein20. Democracy and the State, Mark E Warren21. Democracy and Citize. (shrink)

In discussions of practical reason we often encounter the view that a fact is a reason for an agent to act only if the fact is capable of moving the agent to act. This view figures centrally in many philosophical controversies, and while taken for granted by some, it is vigorously disputed by others. In this essay I show that if the disputed position is correctly interpreted, it is well armored against stock objections and implied by a premise that is (...) not only plausible, but generally accepted by the position's critics. (shrink)

Introduction -- Building blocks -- The old way of thinking -- The new way -- Grammar and philosophy -- The grammar of mathematics -- The grammar of experience -- The grammar of psychology -- Part II -- What does it all mean?

The question "Why should I be moral?," taken as a request for reasons to be moral, strikes many philosophers as silly, confused, or otherwise out of line. Hence we find many attempts to dismiss it as spurious. This paper addresses four such attempts and shows that they fail. It does so partly by discussing various errors about reasons for action, errors that lie at the root of the view that "Why should I be moral?" is ill-conceived. Such errors include the (...) mistake of confusing different uses of "moral reason for A to ø" and the mistake of treating as axiomatic, as in need of no argument, the view that moral considerations furnish every agent with practical reasons. Among the philosophers discussed are John Hospers, Philippa Foot, Stephen Toulmin, H. A. Prichard, and William Frankena. (shrink)

A familiar claim, meant as a challenge to moral knowledge, is that we can credibly accept putative moral facts just in case they explain natural facts. This paper critically addresses Elizabeth Tropman’s response to a version of that claim. Her response has interest partly because it falls within, and extends, an influential philosophical tradition – that of trying to expose (some) skeptical challenges as spurious or ill-conceived. Also, Tropman’s target is not just any version of the claim just mentioned. It (...) is Gilbert Harman’s classic version, according to which putative moral facts must earn credibility by explaining the formation of moral beliefs. This version has wide influence, and variations of it can arise in many areas. Tropman’s response is thus well worth attention. (shrink)

This is a brief reference article on William Wollaston's moral theory, including some influential objections to it.

This is the first clear and non-technical introduction to philosophy through the works of the 18th century philosopher, David Hume. It covers every major philosophical issue commented upon by Hume, from epistemology, philosophy of mind, and metaphysics, to ethics and political philosophy, and the philosophy of religion.

An accessible and relevant introduction to the ancient Indian linguistic tradition, this book assesses the influence of Indian linguistic thought on Western linguistics. It is essential reading for scholars and students of theoretical and historical linguistics, as well as those interested in Indian languages, and Indian/South Asian Studies.

The rift which has long divided the philosophical world into opposed schools-the "Continental" school owing its origins to the phenomenology of Husserl and the "analytic" school derived from Frege-is finally closing.

This volume is devoted entirely to exploring the role of animals in the thought of Immanuel Kant. Leading scholars address questions regarding the possibility of objective representation and intentionality in animals, the role of animals in Kant's scientific picture of nature, the status of our moral responsibilities to animals' welfare, and more.

The key to understanding self-identity is identifying the transcendental structures that make a temporally extended, continuous, and unified experiential life possible. Self-identity is rooted in the formal, temporalizing structure of intentional experience that underlies psychological continuity. Personal identity, by contrast, is rooted in the content of the particular flow of experience, in particular and primarily, in the convictions adopted passively or actively in reflection by a self-identical subject in the light of her social and traditional inheritances. Secondarily, a person’s identity (...) is rooted in others’ characterizations of that person in the light of the social conventions and constructs of the cultures and traditions that have shaped the personal identity of the ones who make the attributions. Personal identity, on this view, is fundamentally rooted in beliefs, traits—especially character traits—sentiments, and moods, that is, in the subject’s convictions about the true, the good, and the right—and in the commitments to the pursuit of (apparently) worthwhile goods and to the practical identities rooted in those convictions. (shrink)

This is done through a chronology, an introductory essay, an extensive bibliography, and hundreds of cross-referenced dictionary entries on key terms and ...

This chapter addresses the issues that motivate representationalist accounts, and it describes the different versions of representationalism as responses to these issues. It argues that the representationalist views do not adequately respond to the epistemological problems that motivate them and that they engender some ontological problems. The chapter presents an alternative ‘presentationalist’ account that preserves the straightforward sense of the mind's openness to the world. While representationalism and presentationalism agree that the relation between mental events or states is direct but (...) mediated, they radically differ in their views of the nature of the mediation involved in the mind's intentional directedness to the world. This difference and the preferability of the presentationalist account are explored. (shrink)

This paper distinguishes between two senses of the term “ phenomenology ”: a narrow sense and a broader sense. It claims, with particular reference to the moral sphere, that the narrow meaning of moral phenomenology cannot stand alone, that is, that moral phenomenology in the narrow sense entails moral intentionality. The paper proceeds by examining different examples of the axiological and volitional experiences of both virtuous and dutiful agents, and it notes the correlation between the phenomenal and intentional differences belonging (...) to these experiences. The paper concludes with some reflections on how the focus on the broader sense of “ phenomenology ” serves to provide a more precise sense of what we might mean by “ moral phenomenology.”. (shrink)

Throughout the history of Western political philosophy, the idea of friendship has occupied a central place in the conversation. It is only in the context of the modern era that friendship has lost its prominence. By retrieving the concept of friendship for philosophical investigation, these essays invite readers to consider how our political principles become manifest in our private lives. They provide a timely corrective to contemporary confusion plaguing this central experience of our public and our private life. This volume (...) assembles essays by well-known scholars who address contemporary concerns about community in the context of philosophical ideas about friendship. Part One includes essays on ancient philosophers including Plato, Aristotle, and Cicero. Part Two considers treatments of friendship by Christian thinkers such as Augustine, Aquinas, Luther, and Calvin, and Part Three continues with Thomas Hobbes, Montaigne, the American founders, and de Tocqueville. The volume concludes with two essays that address the postmodern emphasis on fragmentation and the dynamics of power within the modern state. “This is an outstanding anthology in every respect. _Friendship and Politics_ brings into focus a topic that lies at the heart of the political, even while it has not always garnered the attention it deserves. Friendship, the contributors demonstrate, is an indispensable concept for the analysis of the bonds of political association. The case is most convincingly made by drawing upon the analyses of the greatest thinkers within the history of political thought.” —_David Walsh, Catholic University of America _ “Contemporary political theory assumes that friendship is a private affair, a human relationship that should be quarantined from explorations of politics. The essays in this volume—uniformly excellent, by our best political thinkers—put those assumptions to the test. Together, the essays point to a conception of politics that necessarily includes the highest and best form of human companionship as a necessary means, and even worthwhile end, of the good life. They consider friendship to be a good and at times a challenge that should properly be the concern of political thought and political action. This is an indispensable volume on the inescapable relationship between friendship and politics.” —_Patrick J. Deneen, Georgetown University_. (shrink)

This paper approaches the intentional structure of the emotions by considering three claims about that structure. The paper departs from the Brentanian and Husserlian ‘priority of presentation claim’. The PPC comprises two theses: intentional feelings and emotions are founded on presenting acts and intentional feelings and emotions are directed specifically to the value-attributes of the presented objects. The paper then considers two challenges to this claim: the equiprimordial claim and the priority of feeling claim. The EC asserts that the presentational (...) and affective dimensions of intentional feelings and emotions are equiprimordial. I respond to this challenge to the PPC by revising it, claiming instead that the founding relations exist between the presentational and affective senses in an experience whose presenting and affective aspects are equiprimordial. The PFC grants priority to the affective, a grant which presupposes the independence of the affective from the presentational. I argue that the PFC is mistaken, and that the revision of the PPC can handle the examples on which the PFC is based. (shrink)

For children, the collateral damage of the COVID-19 pandemic response has been considerable. In this paper, we use the framework of evidence-based medicine to argue that child abuse is another negative side effect of COVID-19 lockdowns. While it was certain that school closures would have profound social and economic costs, it remains uncertain whether they have any effect on COVID-19 transmission. There is emerging evidence that lockdowns significantly worsened child abuse on a global scale. Low-income and middle-income countries are particularly (...) vulnerable to increases in child abuse. The best available external evidence from systematic research during the pandemic demonstrates an increase in the risk of child maltreatment, an increase in child maltreatment hospitalisations and a concerning decrease in official child maltreatment referrals. The paradoxical phenomenon of increased hospitalisations and decreased reports is unlikely to be explained by a genuine decrease in child abuse. We conclude that lockdowns have an unacceptably high risk of negative side effects for children, as evidenced by child abuse, the true extent of which appears to be masked by lockdown-related disruptions to schools and other surveillance systems. The desire for a sense of security may be a tempting bias towards emphasising the resilience of children, but it is ethically problematic to push children towards abuse in the name of public health. It is our view that the collateral damage of prolonged school closures for society’s most vulnerable members is a powerful ethical consideration against any pandemic response which involves their use. (shrink)